NORMAN WEISSMAN AND MARTIN PERLMUTTER TABLE II Uptake of Serum Case Jul PBI
نویسنده
چکیده
The clinical picture of acute thyroiditis 8 may be so classical that the diagnosis is obvious. However, very often, the symptomatology may be obscure. Several investigators have sought for a laboratory test, specific for the disease, to complement the clinical observations. In 1949, Werner, Quimby, and Schmidt (1) reported that six patients with thyroiditis had exceedingly low thyroidal uptakes of radioactive iodine. Hamilton, Kirkendall, and Barker (2), in addition to confirming this isotopic finding, also reported that the level of serum protein bound iodine (PBI) was either high normal or abnormally high. These two laboratory findings have helped to diagnose many obscure cases of thyroiditis. Patients who have ingested or received an injection of iodide compounds, may also show low thyroidal uptake of I-131 and an elevation of the serum PBI. Therefore, it would be helpful to have a test, not dependent on iodine metabolism, confirmatory of the disease. One year ago, we studied a patient whose fever of unknown origin proved to be due to thyroiditis. In addition to the above mentioned abnormalities in iodine metabolism, we noted a markedly abnormal electrophoretic serum protein pattern. This abnormality consisted of an increase in alpha-i, alpha-2, and gamma globulin. Since this chance observation, we have examined the electrophoretic patterns of the sera of seven other patients who had subacute thyroiditis. All eight electrophoretic patterns were similar. After these data
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